|
T60028 |
MM41
|
|
DNA/RNA Synthesis
|
|
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line. |
|
T8439 |
Clobenpropit dihydrobromide
|
|
Apoptosis
,
Histamine Receptor
|
|
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07) |
|
T9050 |
AG-270
|
|
Others
,
Methionine Adenosyltransferase (MAT)
|
|
AG-270 is an allosteric and orally active inhibitor of MAT2A. |
|
T21773 |
SP-141
|
SP 141 |
Mdm2
|
|
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. |
|
T9593 |
Senaparib
|
IMP4297 |
PARP
|
|
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity. |
|
T14779 |
BRD7389
|
|
SGK
,
FLT
,
Pim
,
CDK
,
S6 Kinase
,
DAPK
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
|
T8901 |
YUM70
|
|
Apoptosis
,
GPR
,
HSP
|
|
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate... |
|
T2613 |
Almorexant
|
ACT 078573 |
OX Receptor
|
|
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
|
T6916 |
OICR-9429
|
OICR 9429 |
Histone Methyltransferase
,
JAK
|
|
OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro. |
|
T9465 |
ZZW-115 hydrochloride
|
|
Apoptosis
,
Others
|
|
ZZW-115 hydrochloride inhibits the activity of NUPR1. |
|
T9831 |
MKC-1
|
Ro-31-7453 |
Apoptosis
,
Akt
,
Microtubule Associated
,
mTOR
|
|
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format... |
|
T15017 |
CU-T12-9
|
|
TLR
|
|
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat... |
|
T2667 |
PIK-75
|
|
Apoptosis
,
DNA-PK
,
PI3K
|
|
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM). |
|
T7539 |
O6-Benzylguanine
|
|
Apoptosis
,
DNA Alkylation
,
DNA/RNA Synthesis
|
|
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
|
T2148 |
Carbidopa monohydrate
|
Carbidopa Hydrate,S(-)-Carbidopa |
Decarboxylase
,
Aryl Hydrocarbon Receptor
|
|
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. |
|
T9240 |
Sulfopin
|
Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- |
Others
|
|
Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo. |
|
T8766 |
GOT1 inhibitor-1
|
GOT1 inhibitor 2c |
Others
|
|
GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. |
|
TQ0157 |
EIPA
|
L593754,MH 12-43 |
Sodium Channel
,
TRP/TRPV Channel
|
|
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
|
T2287 |
PIK-75 hydrochloride
|
PIK-75 HCl,PIK-75 |
Apoptosis
,
DNA-PK
,
PI3K
|
|
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays. |
|
T6823 |
E3330
|
|
HIF/HIF Prolyl-Hydroxylase
,
DNA/RNA Synthesis
|
|
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
|
T6155 |
Almorexant hydrochloride
|
ACT-078573 hydrochloride,Almorexant HCl |
OX Receptor
|
|
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
|
T62536 |
S100P-IN-1
|
|
Others
|
|
S100P-IN-1 is a potent S100P inhibitor.S100P-IN-1 has anti-metastatic effects on pancreatic cancer (pancreatic) cells. |
|
T35329L |
EAD1 TFA(1644388-26-0 Free base)
|
EAD1 HCL(1644388-26-0 Free base) |
Apoptosis
,
Autophagy
|
|
EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis |
|
T10655 |
C-Met inhibitor 1
|
|
c-Met/HGFR
|
|
c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer. |
|
T1755 |
LY2090314
|
|
GSK-3
|
|
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a... |
|
T11718 |
JI051
|
JI-051 |
Gamma-secretase
|
|
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inh... |
|
T7397 |
GSK547
|
GSK'547 |
RIP kinase
|
|
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. |
|
T6084 |
Rabusertib
|
LY2603618,IC-83 |
Chk
,
PDK
,
Autophagy
|
|
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance... |
|
T77407 |
Ensituximab
|
NPC-1C,NEO-102,NEO-101 |
|
|
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer. |
|
T16964 |
SYM2206
|
SYM-2206,SYM 2206 |
Sodium Channel
,
iGluR
|
|
SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated sustained currents and decreasing the survival of pancreati... |
|
T39403 |
Avotaciclib
|
BEY1107,Avotaciclib |
CDK
|
|
Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastatic pancreatic cancer. |
|
T78212 |
RMC-9805
|
KRAS G12D inhibitor 18,KRAS G12D IN 18 |
Others
|
|
RMC-9805 is a potent KRAS G12D inhibitor with potential anti-tumor and inhibitory activity against tumor cell proliferation for the study of pancreatic cancer. |
|
T11141 |
E64FC26
|
|
Others
|
|
E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer. |
|
T61486 |
DHFR-IN-4
|
|
DHFR
|
|
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer. |
|
T77745 |
N6F11
|
|
GPX
|
|
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer. |
|
T9089 |
FTO-IN-1
|
UUN44923 |
Others
|
|
UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a h... |
|
T70087 |
EPZ032597
|
|
Histone Methyltransferase
|
|
EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and can be used to prevent and treat pancreatic cancer. |
|
T68096 |
Ly-295501
|
ILX-295501,Ly 295501,Ly295501 |
Others
|
|
Ly-295501 (ILX-295501) showed antitumor and anticancer activity in human pancreatic cancer xenotransplantation model. |
|
T6157 |
Devimistat
|
CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid |
Apoptosis
,
Dehydrogenase
,
Mitochondrial Metabolism
|
|
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent... |
|
T6345 |
Tirbanibulin
|
KX2-391,KX-01 |
Microtubule Associated
,
Src
|
|
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibit... |
|
T16549 |
PKI-166
|
|
VEGFR
|
|
PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cance... |
|
T4683 |
Alovudine
|
3'-Deoxy-3'-fluorothymidine |
Antiviral
|
|
Alovudine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and is a better biomarker in pancreatic cancer. |
|
T67291 |
2′,2′-Difluorodeoxyuridine
|
dFdU,2',2'-Difluoro-2'-deoxyuridine |
Drug Metabolite
|
|
2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine.2′,2′-Difluorodeoxyuridine has anticancer and antitumor activity, and shows radiosensitization under hypoxic conditions, and can be used to study p... |
|
T4400 |
DIM-C-pPhOH
|
CDIM8 |
Apoptosis
,
Others
|
|
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... |
|
T64374 |
QN523
|
|
Autophagy
|
|
QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autop... |
|
T77191 |
Clivatuzumab
|
|
Others
|
|
Clivatuzumab is a humanized anti-myxinomab, which can target the MUC1 epitope highly expressed on the surface of most pancreatic cancer cells, and has a good therapeutic effect on a variety of tumor cells. |
|
T60039 |
KSQ-4279
|
USP1-IN-1 |
PARP
,
DUB
|
|
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
|
T39189 |
3,4,5-Trihydroxycinnamic acid decyl ester
|
|
Apoptosis
|
|
3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor with anticancer activity that induces apoptosis.3,4,5-Trihydroxycinnamic acid decyl ester has anti-obesity effects, inhibits lipid uptake and acc... |
|
T67924 |
ABzOH
|
|
|
|
ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express... |
|
T63136 |
DX3-213B
|
|
OXPHOS
|
|
DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM)... |
